Understanding how specific immune cells develop to fight tumors and viruses
Molecular Basis of cDC1 Development
This study is looking at a special type of immune cell that helps fight cancer and viruses, to better understand how it works and how we can use this knowledge to create better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11098519 on NIH RePORTER |
What this research studies
This research investigates the development of classical dendritic cells (cDC1), which play a crucial role in activating CD8 T cells that target tumors and virally infected cells. By examining the genetic and molecular differences between cDC1 and other immune cells, the study aims to enhance our understanding of how these cells process and present antigens to T cells. The methodology includes advanced techniques like ATAC sequencing to analyze chromatin accessibility, which helps in understanding the regulatory mechanisms involved in cDC1 development. Patients may benefit from insights that could lead to improved immunotherapies for cancer and viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with tumors or viral infections who may benefit from enhanced immune responses.
Not a fit: Patients with autoimmune diseases or those not currently facing tumors or viral infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies that enhance the body's ability to fight tumors and viral infections.
How similar studies have performed: Other research has shown promising results in enhancing immune responses through similar approaches, indicating a potential for success in this area.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Murphy, Kenneth M — Washington University
- Study coordinator: Murphy, Kenneth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.