Understanding how specific immune cells affect the spread of colorectal cancer
Delineating the role of SPP1+ macrophages in colorectal cancer metastasis
This study is looking at how certain immune cells called SPP1+ macrophages help metastatic colorectal cancer spread, and it aims to find new ways to improve treatment for patients with this type of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11074839 on NIH RePORTER |
What this research studies
This research investigates the role of SPP1+ macrophages in the spread of metastatic colorectal cancer (mCRC). By using advanced three-dimensional models, the study aims to understand how these immune cells interact with tumor cells and contribute to cancer migration and invasion. The researchers will compare the behavior of normal macrophages to those genetically modified to lack the SPP1 gene, providing insights into their functions in the tumor microenvironment. This approach could reveal new therapeutic targets for improving treatment outcomes in mCRC patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic colorectal cancer who are seeking new treatment options.
Not a fit: Patients with early-stage colorectal cancer or those who do not have colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating metastatic colorectal cancer.
How similar studies have performed: Other research has shown promising results in targeting immune cells in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Hayden Gephart, Melanie — Stanford University
- Study coordinator: Hayden Gephart, Melanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.