Understanding how specific immune cells affect the spread of colorectal cancer
Delineating the role of SPP1+ macrophages in colorectal cancer metastasis
This study is looking at how certain immune cells called SPP1+ macrophages help colorectal cancer spread in the body, using special lab techniques to better understand how cancer cells behave and interact with their surroundings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11073656 on NIH RePORTER |
What this research studies
This research investigates the role of SPP1+ macrophages in the process of colorectal cancer metastasis. By utilizing advanced in vivo and in vitro models, the team aims to replicate the steps involved in cancer spread, allowing for detailed observation and analysis of cell behavior. The study combines experimental methods with computational analysis to uncover how tumor cells interact with their environment during metastasis, focusing on the stressors they encounter and the resulting cellular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, particularly those with metastatic disease.
Not a fit: Patients with non-cancerous conditions or those with localized colorectal cancer without metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that inhibit the spread of colorectal cancer, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding cancer metastasis through similar experimental approaches, indicating potential for success in this area.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Kamm, Roger D — Massachusetts Institute of Technology
- Study coordinator: Kamm, Roger D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.