Understanding how specific heart channels affect heart rhythm and disease mechanisms
Official title: ELECTROMECHANICAL COUPLING AND DISEASE MECHANISMS OF MYOCARDIAL CNBD FAMILY CHANNELS
Funded at Saint Louis University · NIH-11192966 · Data updated 2026-11-12
This study is looking at how certain channels in the heart affect its electrical activity and rhythm, which could help find new ways to treat heart rhythm problems like atrial fibrillation and long QT syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 21, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $620,371 |
| NIH project number | 1R56HL169176-01A1 |
| Project ID | NIH-11192966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with diagnosed arrhythmias or genetic predispositions to conditions like long QT syndrome.
✕Less likely to help
Patients with non-cardiac conditions or those without any history of heart rhythm issues may not benefit from this research.
What this research studies
This research investigates the role of the CNBD family of channels in the heart, particularly focusing on how they influence electrical activity and heart rhythm. By examining hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and KCNH channels, the study aims to uncover mechanisms that could lead to new treatments for arrhythmias, including atrial fibrillation and long QT syndrome. The research involves detailed analysis of channel behavior and the effects of genetic mutations on heart function, which could provide insights into better management of cardiac conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing serious heart rhythm disorders.
How similar studies have gone: Previous research has shown promise in targeting similar cardiac channels for therapeutic interventions, indicating potential for success in this area.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Dai, Gucan — Saint Louis University
- Study coordinator: Dai, Gucan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.