Understanding how specific heart chambers grow after birth
Official title: Novel Signaling Mechanism in Chamber-Specific Postnatal Heart Growth
Funded at University of California Los Angeles · NIH-11111277 · Data updated 2026-11-12
This study looks at how different parts of the heart grow in young mice, hoping to learn more about the signals that help the heart develop properly, which could lead to new treatments for heart problems in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 5R01HL163025-03 |
| Project ID | NIH-11111277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include infants and adolescents with congenital heart defects or other cardiac abnormalities.
✕Less likely to help
Patients with fully developed hearts or those without any cardiac conditions may not receive direct benefits from this research.
What this research studies
This research investigates the unique mechanisms that drive the growth of different chambers of the heart during the early stages of life. By studying neonatal mouse hearts, the researchers have identified specific signaling pathways that are crucial for the development of the right and left ventricles. The study aims to manipulate these pathways to better understand their roles in heart growth and how disruptions can lead to heart diseases. Patients may benefit from insights gained about heart development and potential new treatments for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating heart diseases related to abnormal heart development.
How similar studies have gone: Other research has shown success in understanding cardiac signaling pathways, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Yokota, Tomohiro — University of California Los Angeles
- Study coordinator: Yokota, Tomohiro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.