Understanding how specific heart cells respond to stress in heart disease.
Cell type-specific function of LMNA during myocardial stress in the development of cardiomyopathy
This study is looking at how changes in the LMNA gene, which is connected to heart problems like dilated cardiomyopathy, affect heart cells when they’re under stress, with the hope of finding new treatments for patients with these gene mutations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10565904 on NIH RePORTER |
What this research studies
This research investigates the role of the LMNA gene, which is linked to heart diseases, particularly dilated cardiomyopathy. It focuses on how mutations in this gene affect different types of heart cells, such as cardiomyocytes and cardiac fibroblasts, during stress. By examining these cellular interactions and their impact on heart function, the research aims to uncover the mechanisms that lead to heart disease progression. Patients may benefit from insights that could lead to targeted therapies for heart conditions related to LMNA mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy or those with known LMNA gene mutations.
Not a fit: Patients with heart conditions unrelated to LMNA mutations or those without a diagnosis of cardiomyopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the cellular mechanisms involved in heart disease, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the cellular roles of LMNA in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Choi, Jason Cheol — Thomas Jefferson University
- Study coordinator: Choi, Jason Cheol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.