Understanding how specific gut bacteria contribute to Alzheimer's disease
Investigating the strain-specific role of Bacteroides in the etiology of Alzheimer's disease
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11103196
This research explores how certain types of Bacteroides bacteria in the gut might play a role in the development and progression of Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11103196 on ClinicalTrials.gov |
What this research studies
We are looking into whether a long-term, low-level infection with specific Bacteroides bacteria contributes to Alzheimer's disease. Our previous work in animal models showed that these bacteria can increase amyloid plaques, a hallmark of Alzheimer's. We also found that these bacteria are more common in people with Alzheimer's and are linked to markers of gut inflammation. This suggests a direct connection to human disease, and we are working to understand the exact ways these bacteria might affect brain changes seen in Alzheimer's.
Who could benefit from this research
Good fit: This foundational research is not currently recruiting patients, but future studies based on this work may seek individuals with Alzheimer's disease or those at risk.
Not a fit: Patients without Alzheimer's disease or related risk factors may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Alzheimer's disease by targeting specific gut bacteria.
How similar studies have performed: Our group was the first to show that Bacteroides can increase amyloid plaques in animal models, indicating a novel and promising area of investigation.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COX, LAURA MICHELLE — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: COX, LAURA MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease model, Alzheimer's disease pathology