Understanding how specific genes regulate immune responses in diseases
Discovery of novel regulatory territories in the TNF/LT locus
This study is looking at how certain genes related to the immune system work, especially in T cells and macrophages, to find new ways to help treat autoimmune diseases linked to the TNF gene, which could lead to better management and treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080206 on NIH RePORTER |
What this research studies
This research investigates the regulatory mechanisms of the TNF gene and related genes in immune cells, particularly T cells and monocytes/macrophages. By utilizing advanced techniques like next generation sequencing and CRISPR editing, the study aims to identify genomic regions that could be targeted for treating diseases driven by TNF. The research focuses on how these genes behave under different conditions, such as activation and infection, to uncover potential therapeutic targets for autoimmune diseases. Patients may benefit from insights gained about how to better manage or treat conditions linked to TNF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or conditions related to TNF dysregulation.
Not a fit: Patients with non-autoimmune conditions or those not affected by TNF-related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for autoimmune diseases and other conditions influenced by TNF.
How similar studies have performed: Previous research has shown success in targeting regulatory elements in gene expression, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Goldfeld, Anne — Boston Children's Hospital
- Study coordinator: Goldfeld, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.