Understanding how specific genes influence pancreatic cancer growth and types
Lineage specifiers governing pancreatic cancer growth and molecular subtype
This study is looking at a tough type of pancreatic cancer to see if it can be divided into two groups based on certain genes, which could help find better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10874388 on NIH RePORTER |
What this research studies
This research investigates pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of cancer with a very low survival rate. It aims to classify PDAC into two main subtypes, Classical and Basal-like, based on the expression of certain genes that dictate the cancer's characteristics. By analyzing human samples, the study seeks to uncover the molecular regulators that differentiate these subtypes and their implications for treatment. The ultimate goal is to identify specific vulnerabilities in these cancer types that could lead to more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma, particularly those with the Basal-like subtype.
Not a fit: Patients with other types of pancreatic cancer or those without a confirmed diagnosis of PDAC may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promise in identifying molecular subtypes of cancers and their therapeutic implications, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Snyder, Eric Lee — University of Utah
- Study coordinator: Snyder, Eric Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.