Understanding how specific genes influence lower jaw development
Official title: The roles of Hsd3b7 and Foxp2 in Lower Jaw Development
Funded at University of Southern California · NIH-11078677 · Data updated 2026-11-12
This study is looking at how two important genes help shape the lower jaw, which could help us understand how the jaw develops and works properly.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | May 1, 2024 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $37,185 |
| NIH project number | 5F32DE033911-02 |
| Project ID | NIH-11078677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital jaw deformities or related developmental disorders.
✕Less likely to help
Patients with acquired jaw injuries or conditions unrelated to genetic development may not benefit from this research.
What this research studies
This research investigates the genetic mechanisms that shape the lower jaw by focusing on two key genes, Hsd3b7 and Foxp2. It aims to understand how these genes interact with signaling pathways to influence the development of jaw cartilage and connective tissues. By using advanced techniques like single-cell sequencing, the project will explore how these genes balance the formation of skeletal and connective tissues in the jaw. This research could provide insights into developmental processes that are crucial for proper jaw function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing jaw development disorders.
How similar studies have gone: Previous research has shown success in understanding genetic influences on jaw development, making this approach promising.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Paulissen, Eric — University of Southern California
- Study coordinator: Paulissen, Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.