Understanding how specific genes are regulated during cell development
Official title: Roles of allele-specific chromatin interactions in transcription regulation during development
Funded at University of Michigan at Ann Arbor · NIH-11006290 · Data updated 2026-11-12
This study is looking at how certain cells in the body change into different types of cells by exploring the way genes work together, which could help us understand the genetic causes of developmental disorders like autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 14, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $246,343 |
| NIH project number | 5R00HG011542-05 |
| Project ID | NIH-11006290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic predispositions to developmental disorders, particularly autism spectrum disorder.
✕Less likely to help
Patients with fully established developmental disorders unrelated to genetic factors may not receive direct benefits from this research.
What this research studies
This research investigates how multipotent cells differentiate into specific cell types by examining the interactions between different regulatory elements in the genome. Using advanced 3D genome technologies, the study will analyze chromatin architecture and gene regulation in mouse embryonic stem cells. By focusing on allele-specific interactions, the research aims to uncover how these interactions influence gene expression and cell differentiation. Patients may benefit from insights gained about the genetic basis of developmental disorders, including autism spectrum disorder.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in developmental disorders, potentially informing new treatment strategies.
How similar studies have gone: Other research has shown promise in understanding gene regulation through 3D genome technologies, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Kim, Minji — University of Michigan at Ann Arbor
- Study coordinator: Kim, Minji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.