Understanding how specific genes are regulated during cell development
Roles of allele-specific chromatin interactions in transcription regulation during development
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11006290
This study is looking at how certain cells in the body change into different types of cells by exploring the way genes work together, which could help us understand the genetic causes of developmental disorders like autism.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11006290 on ClinicalTrials.gov |
What this research studies
This research investigates how multipotent cells differentiate into specific cell types by examining the interactions between different regulatory elements in the genome. Using advanced 3D genome technologies, the study will analyze chromatin architecture and gene regulation in mouse embryonic stem cells. By focusing on allele-specific interactions, the research aims to uncover how these interactions influence gene expression and cell differentiation. Patients may benefit from insights gained about the genetic basis of developmental disorders, including autism spectrum disorder.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic predispositions to developmental disorders, particularly autism spectrum disorder.
Not a fit: Patients with fully established developmental disorders unrelated to genetic factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in developmental disorders, potentially informing new treatment strategies.
How similar studies have performed: Other research has shown promise in understanding gene regulation through 3D genome technologies, indicating that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, MINJI — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KIM, MINJI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder