Understanding how specific genes are expressed based on parental origin
Systematic elucidation of allele specific proteome at Imprint Control Regions
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-10781961
This study is looking at how some genes from our parents work differently, which is important for healthy baby development, and it aims to find out more about the proteins that control these genes to help us understand certain rare genetic disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10781961 on ClinicalTrials.gov |
What this research studies
This research investigates the process of genomic imprinting, which is how certain genes are expressed differently depending on whether they come from the mother or father. It focuses on understanding the protein complexes that regulate these imprinted genes, which are crucial for proper embryonic development. By using advanced techniques to target specific regions of the genome and label proteins, the researchers aim to uncover the mechanisms behind this selective gene expression. This knowledge could help in understanding rare genetic disorders linked to imprinted genes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known imprinting disorders or those with a family history of such conditions.
Not a fit: Patients without any genetic disorders or those not affected by imprinting-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for complex genetic disorders related to imprinted genes.
How similar studies have performed: Previous research has shown promise in understanding genomic imprinting, but this specific approach is relatively novel and untested.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOTA, SATYA K. — HARVARD MEDICAL SCHOOL
- Study coordinator: KOTA, SATYA K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.