Understanding how specific genes affect blood vessel health in pulmonary arterial hypertension.
SOX17/RUNX1 Axis Regulates Endothelial Cell Fate in the Pathogenesis of Pulmonary Arterial Hypertension
This study is looking at how changes in certain genes might cause problems with blood flow in the lungs for people with pulmonary arterial hypertension (PAH), and it hopes to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10870064 on NIH RePORTER |
What this research studies
This research investigates the role of the SOX17 and RUNX1 genes in the development of pulmonary arterial hypertension (PAH), a serious condition that affects blood flow in the lungs. The study aims to understand how mutations in the SOX17 gene can lead to abnormal blood vessel formation and increased risk of PAH. By examining patient-derived cells, researchers will explore how these genetic factors contribute to the disease and identify potential new therapies. The approach includes analyzing the effects of gene alterations on endothelial cell behavior and vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary arterial hypertension, particularly those with mutations in the SOX17 gene.
Not a fit: Patients without pulmonary arterial hypertension or those whose condition is unrelated to the SOX17/RUNX1 genetic pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively halt or reverse the progression of pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in targeting genetic pathways in vascular diseases, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Liang, Olin D. — Rhode Island Hospital
- Study coordinator: Liang, Olin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.