Understanding how specific genes affect Behcet's eye disease
Unraveling the role of HLA-B51/ERAP1 in Behcet's eye disease
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10997433
This study is looking at how certain genes might affect the immune system in people with Behcet's eye disease, with the hope of finding better treatments for those living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10997433 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the HLA-B51 gene and the ERAP1 haplotype in patients with Behcet's eye disease. By analyzing immune responses and cell functions in affected individuals, the study aims to uncover how these genetic factors contribute to the disease. The researchers will utilize advanced techniques, including flow cytometry and single-cell transcriptomics, to gather detailed information from patient samples. This knowledge could lead to better-targeted therapies for those suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Behcet's eye disease, particularly those who carry the HLA-B51 gene.
Not a fit: Patients without Behcet's eye disease or those who do not carry the HLA-B51 gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with Behcet's eye disease.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOWATZKY, JOHANNES — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: NOWATZKY, JOHANNES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adamantiades-Behcet's Syndrome