Understanding how specific gene mutations affect leukemia treatment
Interrogating the minor spliceosome to understand and treat leukemia
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10876993
This study is looking at how changes in the ZRSR2 gene affect leukemia, especially in people with myelodysplastic syndromes, to find better ways to treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10876993 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mutations in the ZRSR2 gene, which is associated with leukemia, particularly in patients with myelodysplastic syndromes. The team aims to explore how these mutations impact the function of RNA splicing and how they can be targeted for therapeutic purposes. By analyzing the genetic and functional consequences of these mutations, the research seeks to improve treatment strategies for leukemia patients. Patients may be involved in studies that assess the effects of these mutations on their condition and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myelodysplastic syndromes or other myeloid malignancies who have mutations in the ZRSR2 gene.
Not a fit: Patients without these specific genetic mutations or those with other types of leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for leukemia by targeting specific genetic mutations.
How similar studies have performed: While the focus on ZRSR2 mutations is relatively novel, similar research on other spliceosomal mutations has shown promising results in understanding and treating leukemia.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABDEL-WAHAB, OMAR — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: ABDEL-WAHAB, OMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers