Understanding how specific gene fusions contribute to blood cancers
Official title: Elucidating the molecular mechanism of Daple- FLT3 and Daple-PDGFRB gene fusion in blood cancers
Funded at California State Poly U Pomona · NIH-11037219 · Data updated 2026-11-12
This study is looking at how certain gene fusions related to blood cancers work, with the hope that understanding them better will help create more effective treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State Poly U Pomona NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $99,295 |
| NIH project number | 3R16GM146720-03S1 |
| Project ID | NIH-11037219 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with hematopoietic malignancies, particularly those with known Daple-FLT3 or Daple-PDGFRB gene fusions.
✕Less likely to help
Patients with blood cancers that do not involve the Daple-FLT3 or Daple-PDGFRB gene fusions may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind the Daple-FLT3 and Daple-PDGFRB gene fusions, which are linked to various blood cancers. By analyzing these gene fusions, the research aims to uncover how they influence cancer development and progression. Patients may benefit from insights that could lead to targeted therapies or improved treatment strategies for hematopoietic malignancies. The approach involves advanced molecular biology techniques to study the interactions and effects of these gene fusions in cancer cells.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with specific blood cancers caused by these gene fusions.
How similar studies have gone: Previous research has shown promising results in understanding gene fusions in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
California State Poly U Pomona
Pomona, United States Active
Researchers
- Principal investigator: Ear, Jason — California State Poly U Pomona
- Study coordinator: Ear, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.