Understanding how specific gene dysfunction affects bladder cancer
Defining the role of histone H3K4 mono-methyltransferase dysfunction in urothelial carcinoma
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10894874
This study is looking at how certain gene changes might affect the development of bladder cancer, and it aims to find out more about these changes using special mouse models, which could help improve diagnosis and treatment for people with this type of cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10894874 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone H3K4 mono-methyltransferase dysfunction in urothelial carcinoma, a type of bladder cancer. It focuses on understanding how mutations in certain genes contribute to the development and progression of this cancer. By using genetically engineered mouse models, the study aims to uncover the mechanisms behind these mutations and their impact on cancer behavior. The findings could lead to better diagnostic and therapeutic strategies for patients with bladder cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with urothelial carcinoma, particularly those with nonmuscle invasive or muscle invasive forms of the disease.
Not a fit: Patients with other types of cancer or those without a diagnosis of urothelial carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with bladder cancer.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors involved in bladder cancer, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YU — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: CHEN, YU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer