Understanding how specific connections form in the brain
Molecular mechanisms of target-specific synapse formation
This study is looking at how a protein called Kirrel3 helps brain cells connect with each other, which is important for understanding mental health issues, and it could lead to new ways to help people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10764199 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that enable neurons to form specific connections, known as synapses, with target neurons in the brain. It focuses on a protein called Kirrel3, which is crucial for the formation of certain synapses that may be linked to mental health disorders. By conducting various laboratory assays, the researchers aim to uncover how Kirrel3 interacts with other molecules to facilitate these connections. The findings could provide insights into the underlying causes of mental illnesses and potentially lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing mental health disorders.
Not a fit: Patients with mental health disorders who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for mental health disorders.
How similar studies have performed: Other research has shown promise in understanding synapse formation, but the specific role of Kirrel3 in this context is still being explored.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Williams, Megan Elise — University of Utah
- Study coordinator: Williams, Megan Elise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.