Understanding how specific chemical modifications of histones affect gene regulation in mammals
Regulation and Function of Histone H3K36 Methylation in Mammalian Chromatin
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10895549
This study is looking at how a specific chemical change in our genes, called H3K36 methylation, affects how our genes work and how our DNA is organized, which could help us understand more about certain brain disorders and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10895549 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone H3K36 methylation in mammalian cells, focusing on how this modification influences gene expression and chromatin structure. The study examines the enzymes responsible for adding these methyl groups, particularly ASH1L and NSD family members, and their implications in neurodevelopmental disorders and cancers. By utilizing advanced techniques such as CRISPR, the research aims to uncover the regulatory mechanisms that control H3K36 methylation and its functional consequences in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with specific genetic mutations related to ASH1L or NSD, as well as patients diagnosed with certain types of cancers linked to histone modifications.
Not a fit: Patients without genetic mutations affecting histone methylation or those not diagnosed with related cancers or neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of gene regulation, potentially informing treatments for cancers and neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding histone modifications and their roles in gene regulation, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LU, CHAO — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: LU, CHAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers