Understanding how specific changes in histone proteins affect gene expression
Official title: Scalable platforms for understudied histone modifications and modifiers
Funded at North Carolina State University Raleigh · NIH-10922667 · Data updated 2026-11-12
This study is looking at how changes to histone proteins can affect how our genes work, which could help us find new ways to treat different diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | September 6, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $325,820 |
| NIH project number | 5R01GM148562-02 |
| Project ID | NIH-10922667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders or diseases where chromatin regulation plays a critical role.
✕Less likely to help
Patients with conditions unrelated to chromatin modifications or gene regulation may not receive any benefit from this research.
What this research studies
This research investigates the complex interactions between histone proteins and DNA, focusing on how specific modifications to histones can influence gene expression and cellular processes. By identifying and quantifying these histone modifications, the study aims to unravel the 'histone code' that dictates how genes are regulated. The approach involves advanced biochemical techniques to assess the interactions between modified histones and other proteins, which is crucial for understanding cellular behavior. Patients may benefit from insights gained into gene regulation that could lead to new therapeutic strategies for various diseases.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding gene regulation, potentially informing new treatments for diseases linked to chromatin dysfunction.
How similar studies have gone: While some research has successfully explored histone modifications, this study aims to address largely understudied areas, making it a novel approach.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Rao, Balaji M — North Carolina State University Raleigh
- Study coordinator: Rao, Balaji M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.