Understanding how specific cells in the lungs help with injury and healing
Molecular regulation of cell fate and progenitor function in the distal human respiratory airways
This study is looking at special lung cells that help with healing after injury, especially in people with COPD, to see how they can change into another type of cell that helps keep your lungs healthy, which could lead to new treatments for lung problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11059097 on NIH RePORTER |
What this research studies
This research focuses on the distal airway epithelium, particularly a unique population of cells known as respiratory airway secretory cells (RASCs), which play a crucial role in lung injury and regeneration. The project aims to investigate how these cells can transform into alveolar type 2 cells, especially in the context of Chronic Obstructive Pulmonary Disease (COPD). The research will utilize advanced techniques in gene editing and bioinformatics to explore the molecular mechanisms regulating these cell functions. Patients may benefit from insights gained into lung repair processes and potential new therapeutic strategies for lung diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from Chronic Obstructive Pulmonary Disease (COPD) or other lung injuries.
Not a fit: Patients with acute respiratory infections or those without chronic lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung healing and regeneration for patients with respiratory diseases.
How similar studies have performed: Other research has shown promising results in understanding lung regeneration mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Basil, Maria Ciocca — University of Pennsylvania
- Study coordinator: Basil, Maria Ciocca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.