Understanding how specific cells in the lungs help maintain airway health
Contribution of pulmonary ionocytes and neuroendocrine cells to ion transport-mediated airway surface liquid maintenance
This study is looking at special lung cells that help keep your airways healthy by managing the movement of important fluids, which could help us understand better how to treat conditions like asthma and COPD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-11074093 on NIH RePORTER |
What this research studies
This research investigates the role of specialized cells in the lungs, known as pulmonary ionocytes and neuroendocrine cells, in regulating ion transport that is crucial for maintaining the airway surface liquid. By studying how these cells contribute to the movement of ions and water, the research aims to uncover their impact on airway function and health. The approach involves analyzing airway epithelial cultures to observe how changes in these cell types affect ion transport properties, which is vital for protecting the airways from irritants and pathogens. This could lead to new insights into conditions like asthma and chronic obstructive pulmonary disease (COPD).
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from asthma or other airway diseases who may benefit from advancements in treatment strategies.
Not a fit: Patients with non-respiratory conditions or those without airway diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory conditions by enhancing our understanding of airway health and disease mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the role of ion transport in airway diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Bratcher, Preston E — National Jewish Health
- Study coordinator: Bratcher, Preston E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.