Understanding how specific cells in the colon respond to inflammation
Official title: Activation of deep crypt secretory cells in colonic inflammation
Funded at Children's Hospital of Los Angeles · NIH-10945113 · Data updated 2026-11-12
This study is looking at special cells in the colon that help keep your gut healthy, to see how they react to inflammation and if they can help heal the colon during conditions like inflammatory bowel disease (IBD), with the hope of finding new treatments that could improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $551,112 |
| NIH project number | 1R01DK140323-01 |
| Project ID | NIH-10945113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory bowel disease or other colonic inflammatory conditions.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders may not receive any benefit from this research.
What this research studies
This research investigates deep crypt secretory (DCS) cells, which are specialized cells in the colon that play a role in maintaining gut health. The study aims to understand how these cells respond to inflammation and whether their activation can help in healing the colon during inflammatory bowel disease (IBD). By examining the mechanisms that regulate these cells, the research seeks to identify potential therapeutic targets for improving colonic health. Patients may benefit from insights that could lead to new treatments for conditions like IBD.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the healing of the colon in patients with inflammatory bowel disease.
How similar studies have gone: Other research has shown promise in targeting specific cell populations for therapeutic purposes, suggesting that this approach could be effective.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Schumacher, Michael Andrew — Children's Hospital of Los Angeles
- Study coordinator: Schumacher, Michael Andrew
Related research
Other NIH-funded projects on the same topics.
-
UMPIRE Protocol: A Urologic Plan to Protect Kidneys in Young Children with Spina Bifida
A coordinated urologic plan is being tested to preserve kidney health in young children with spina bifida by standardizing care and collecting data across multiple sites.
-
National Spina Bifida Patient Registry, Component B
This project continues collecting and sharing information from people with spina bifida to improve care and outcomes.
-
NEUROG3's role in forming pancreatic progenitor cells
Researchers are studying how a NEUROG3 gene flaw in patient-derived stem cells affects the development of pancreas cells that can later become insulin-producing cells.
-
Point-of-care brain MRI for kids with head injuries
A fast, bedside MRI test using a portable low-field machine for children with head trauma to help doctors decide next steps without exposing them to radiation.
-
Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
-
Brain and Cognitive Development in kids exposed to alcohol before birth
This grant would study how prenatal alcohol exposure affects brain and thinking skills in children and teens from a South African birth cohort, using follow-up brain imaging and cognitive tests.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.