Understanding how specific cells in the colon respond to inflammation
Activation of deep crypt secretory cells in colonic inflammation
This study is looking at special cells in the colon that help keep your gut healthy, to see how they react to inflammation and if they can help heal the colon during conditions like inflammatory bowel disease (IBD), with the hope of finding new treatments that could improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10945113 on NIH RePORTER |
What this research studies
This research investigates deep crypt secretory (DCS) cells, which are specialized cells in the colon that play a role in maintaining gut health. The study aims to understand how these cells respond to inflammation and whether their activation can help in healing the colon during inflammatory bowel disease (IBD). By examining the mechanisms that regulate these cells, the research seeks to identify potential therapeutic targets for improving colonic health. Patients may benefit from insights that could lead to new treatments for conditions like IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel disease or other colonic inflammatory conditions.
Not a fit: Patients with non-inflammatory gastrointestinal disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the healing of the colon in patients with inflammatory bowel disease.
How similar studies have performed: Other research has shown promise in targeting specific cell populations for therapeutic purposes, suggesting that this approach could be effective.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Schumacher, Michael Andrew — Children's Hospital of Los Angeles
- Study coordinator: Schumacher, Michael Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.