Understanding how specific cells in the colon control its movements
Role of interstitial cells of Cajal in patterned colonic motor activity
This study is looking at special cells in the colon that help control how it moves, which is important for digestion, to better understand how problems with these movements can affect people with digestive issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project ID | NIH-11023072 on NIH RePORTER |
What this research studies
This research investigates the role of interstitial cells of Cajal (ICC) in regulating the contractions of the colon, which are essential for proper digestion. By examining how these cells interact with smooth muscle cells and motor neurons, the study aims to uncover the mechanisms behind colonic motility. The research will focus on understanding the calcium signaling in ICC and how it contributes to coordinated contractions in the colon. This could lead to insights into various gastrointestinal motility disorders that affect patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing gastrointestinal motility disorders, such as constipation or irritable bowel syndrome.
Not a fit: Patients with motility disorders unrelated to the function of interstitial cells of Cajal may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from gastrointestinal motility disorders.
How similar studies have performed: Previous studies have shown promising results in understanding ICC in other parts of the gastrointestinal tract, suggesting potential for success in this area as well.
Where this research is happening
Reno, United States
- University of Nevada Reno — Reno, United States (Active)
Researchers
- Principal investigator: Baker, Sal — University of Nevada Reno
- Study coordinator: Baker, Sal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.