Understanding how specific cells help muscles heal after injury
Official title: Fibroadipogenic progenitor cells as drivers of angiogenesis during muscle regeneration
Funded at University of Missouri-Columbia · NIH-10741438 · Data updated 2026-11-12
This study is looking at how certain cells in your body help muscles heal after injuries, especially in your arms and legs, to find ways to improve recovery and create better treatments for muscle injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $420,883 |
| NIH project number | 1R21HD110771-01A1 |
| Project ID | NIH-10741438 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced significant muscle injuries, particularly those resulting in volumetric muscle loss.
✕Less likely to help
Patients with minor muscle injuries or those whose injuries do not involve significant tissue loss may not benefit from this research.
What this research studies
This research investigates the role of fibroadipogenic progenitor cells in the healing process of skeletal muscle after traumatic injuries, particularly in the limbs. By using a novel mouse model, the study aims to uncover the cellular and molecular mechanisms that differentiate between successful muscle regeneration and cases where regeneration fails. The approach involves analyzing the interactions between various cell types, including muscle stem cells and endothelial cells, to better understand how to enhance muscle recovery. This knowledge could lead to new therapies that activate the body's natural healing processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals with severe muscle injuries, enhancing their recovery and quality of life.
How similar studies have gone: Previous research has shown promise in understanding muscle regeneration, but this specific approach focusing on fibroadipogenic progenitor cells is relatively novel.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Segal, Steven S — University of Missouri-Columbia
- Study coordinator: Segal, Steven S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.