Understanding how specific cells contribute to lung fibrosis in aging
Deciphering the role of p16INK4A+ fibroblasts in lung fibrosis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10999407
This study is looking at special cells in the lungs of older adults to see how they might contribute to lung scarring, which can help us understand more about lung problems that come with age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10999407 on ClinicalTrials.gov |
What this research studies
This research investigates the role of p16INK4A+ fibroblasts in the development of lung fibrosis, particularly in older adults. By using a novel genetic reporter system, the study aims to isolate and characterize these specific cells in living tissues, which could help clarify their contributions to age-related lung diseases. The approach combines advanced genetic engineering with in vivo and ex vivo analysis to provide insights into how these cells behave in the context of lung fibrosis. This could lead to a better understanding of the mechanisms behind chronic lung diseases associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing or are at risk for idiopathic pulmonary fibrosis.
Not a fit: Patients with lung fibrosis not related to aging or those with other unrelated chronic lung diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lung fibrosis and improving outcomes for older patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of senescent cells in various age-related diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENG, TIEN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: PENG, TIEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder