Understanding how specific cell receptors help cells stick together and communicate
Official title: Structural and Functional Characterization of CELSR-subfamily adhesion G protein-coupled receptors
Funded at University of Chicago · NIH-11033789 · Data updated 2026-11-12
This study is looking at special proteins on cell surfaces called CELSRs that help cells stick together and talk to each other, which could help us understand how they relate to developmental disorders and Tourette syndrome.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $108,793 |
| NIH project number | 1K99GM157487-01 |
| Project ID | NIH-11033789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with developmental disorders or conditions associated with CELSR mutations.
✕Less likely to help
Patients without any known genetic mutations related to CELSRs or those not affected by developmental disorders may not benefit from this research.
What this research studies
This research focuses on a group of cell-surface receptors known as CELSRs, which play a crucial role in how cells adhere to each other and communicate. By investigating the structure and function of these receptors, the research aims to uncover their involvement in important developmental processes and diseases. The approach includes advanced imaging techniques and bioinformatics to analyze how these receptors interact and signal within cells. This could lead to a better understanding of conditions linked to CELSR mutations, such as developmental disorders and Tourette syndrome.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to new therapeutic strategies for developmental disorders and related conditions.
How similar studies have gone: While the specific focus on CELSRs is relatively novel, similar research on cell adhesion receptors has shown promising results in understanding developmental processes and disease mechanisms.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Bandekar, Sumit — University of Chicago
- Study coordinator: Bandekar, Sumit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.