Understanding how specific cell processes affect brain aneurysms
Role of Selective Autophagy of Focal Adhesion in Intracranial Aneurysm
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11000770
This study is looking into how certain proteins in brain blood vessel cells might affect the growth of dangerous bulges called intracranial aneurysms, with the hope of finding new ways to help people who have this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11000770 on ClinicalTrials.gov |
What this research studies
This research investigates the role of selective autophagy in the formation and progression of intracranial aneurysms, which are dangerous bulges in the blood vessels of the brain. The study aims to uncover the molecular mechanisms behind these aneurysms by focusing on how certain proteins interact within endothelial cells. By using advanced techniques, researchers will explore how these cellular processes impact the integrity of blood vessels and contribute to aneurysm development. The ultimate goal is to identify new therapeutic targets that could lead to better treatment options for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with intracranial aneurysms.
Not a fit: Patients with other types of vascular conditions unrelated to intracranial aneurysms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for preventing or managing intracranial aneurysms.
How similar studies have performed: While the specific approach of targeting selective autophagy in this context is novel, similar studies have shown promise in understanding vascular diseases.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUI, YANNING — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: RUI, YANNING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.