Understanding how specific cell groups help form the brain during development
Official title: Molecular identification of the isthmic organizer
Funded at University of Colorado Denver · NIH-11094895 · Data updated 2026-11-12
This study is looking at a special area in the brain that helps guide its development, and it's for anyone interested in understanding how problems in this process might lead to brain disorders.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $191,311 |
| NIH project number | 5R21NS137568-02 |
| Project ID | NIH-11094895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurodevelopmental disorders, particularly those related to brain formation and function.
✕Less likely to help
Patients with fully developed neurological conditions unrelated to developmental processes may not receive benefit from this research.
What this research studies
This research investigates the role of signaling centers, known as organizers, in the development of the central nervous system (CNS). It focuses on the isthmic organizer, a key area where specific cells produce factors that guide the formation and differentiation of adjacent neural structures. By studying the cellular and molecular components of the isthmic organizer, the research aims to uncover how these organizers function and how their dysfunction can lead to developmental disorders. Patients may benefit from insights gained into the mechanisms of brain development and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental disorders and potential new therapeutic approaches for conditions like autism and other neurodevelopmental disorders.
How similar studies have gone: Previous research has shown success in understanding other organizers in CNS development, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Sagerstrom, Charles G — University of Colorado Denver
- Study coordinator: Sagerstrom, Charles G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.