Understanding how specific brain receptors affect memory and behavior in schizophrenia
Distinct NMDA receptor signaling domains regulate hippocampal network dynamics
This study is looking at how certain brain receptors affect memory and thinking in young people with schizophrenia, hoping to find new ways to help them understand and manage their condition better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Mason University NIH-funded |
| Lab location | 1 site (Fairfax, United States) |
| Project ID | NIH-10988852 on NIH RePORTER |
What this research studies
This research investigates the role of distinct NMDA receptor signaling domains in the hippocampus, which is crucial for memory and cognitive functions. By examining how these receptors influence brain network dynamics, the study aims to uncover the underlying mechanisms of schizophrenia, particularly in adolescents and young adults. The approach involves advanced techniques to analyze brain activity and its relationship with cognitive processes, potentially leading to new insights into treatment strategies for schizophrenia. Patients may benefit from a better understanding of their condition and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents and young adults aged 12-20 who are experiencing symptoms of schizophrenia or related cognitive disorders.
Not a fit: Patients outside the age range of 12-20 or those not diagnosed with schizophrenia may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for schizophrenia, enhancing cognitive function and quality of life for affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding NMDA receptor functions in schizophrenia, suggesting that this approach may yield valuable insights.
Where this research is happening
Fairfax, United States
- George Mason University — Fairfax, United States (Active)
Researchers
- Principal investigator: Dumas, Theodore C — George Mason University
- Study coordinator: Dumas, Theodore C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.