Understanding how specific brain pathways affect persistent pain
The Role of Distinct Dorsal Column Nuclei Outputs in Persistent Pain
['FUNDING_CAREER'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-10887232
This study is looking at how a part of the brain called the dorsal column nuclei affects the way we feel touch and pain, especially for people who experience pain when they touch something, with the hope of finding new ways to help manage that pain.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-10887232 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the dorsal column nuclei (DCN) in the brainstem, which processes touch sensations and their relationship to persistent pain. By examining how the DCN connects to other brain areas involved in pain perception and suppression, the study aims to uncover the mechanisms that lead to touch-evoked pain. The research employs advanced techniques such as ablation, electrical stimulation, and pharmacological interventions to explore these pathways. Patients may benefit from insights that could lead to new pain management strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain conditions, particularly those with touch-evoked pain.
Not a fit: Patients with acute pain or those not experiencing persistent pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from persistent pain.
How similar studies have performed: Previous research has shown promising results in understanding pain pathways, but this specific approach is relatively novel.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRADWELL, MARK — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: GRADWELL, MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.