Understanding how specific brain pathways affect mood and addiction.
Official title: Connectivity and Function of the Asymmetric Habenulo-Interpeduncular Pathway
Funded at Dartmouth College · NIH-10983298 · Data updated 2026-11-12
This study is looking at a specific part of the brain that affects sleep, anxiety, and addiction to better understand how it works when we face negative experiences, which could help find new ways to treat mood disorders and addiction.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $500,200 |
| NIH project number | 5R37HD091280-09 |
| Project ID | NIH-10983298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing mood disorders or addiction-related issues.
✕Less likely to help
Patients with neurological conditions unrelated to mood or addiction may not benefit from this research.
What this research studies
This research investigates the habenulo-interpeduncular pathway in the brain, which plays a crucial role in various functions such as sleep, anxiety, and addiction. By using advanced techniques like genetic manipulation and imaging, the study aims to identify different types of neurons in this pathway and how they respond to negative experiences. This could help in understanding the underlying mechanisms of mood disorders and addiction, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for mood disorders and addiction.
How similar studies have gone: Previous research has shown promising results in understanding brain pathways related to addiction and mood disorders, indicating that this approach has potential for success.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Halpern, Marnie E — Dartmouth College
- Study coordinator: Halpern, Marnie E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.