Understanding how specific brain neurons control hunger and energy balance
Official title: Mechanisms of action for dorsomedial hypothalamic Lepr-Glp1r neurons that control feeding and energy balance
Funded at University of Michigan at Ann Arbor · NIH-10909055 · Data updated 2026-11-12
This study is looking at how specific brain cells help control hunger and energy use, with the hope of finding new ways to treat obesity and related issues, so that people can better manage their appetite and weight.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,644 |
| NIH project number | 5F31DK137390-02 |
| Project ID | NIH-10909055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adults struggling with obesity or type 2 diabetes.
✕Less likely to help
Patients who are not affected by obesity or type 2 diabetes may not receive any benefit from this research.
What this research studies
This research investigates the role of certain neurons in the brain's hypothalamus that regulate feeding behavior and energy balance. By examining how these neurons respond to hormonal signals like leptin, the study aims to uncover mechanisms that could lead to new treatments for obesity and related conditions. The approach involves detailed analysis of neuronal circuits and their interactions, which may provide insights into how to better manage appetite and body weight. Patients may benefit from potential therapies developed from this understanding.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and type 2 diabetes, improving health outcomes for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding brain mechanisms related to appetite control, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Duensing, Allison — University of Michigan at Ann Arbor
- Study coordinator: Duensing, Allison
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.