Understanding how specific brain neurons control glucose release during stress
Identifying functional and anatomic mechanisms of glucose mobilization by cholecystokinin b receptor containing neurons in the ventromedial nucleus of the hypothalamus
This study is looking at how certain brain cells help your body manage sugar and fat when you're stressed, which could help us understand how long-term stress might lead to diabetes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10869944 on NIH RePORTER |
What this research studies
This research investigates the role of cholecystokinin B receptor-containing neurons in the ventromedial nucleus of the hypothalamus, which are believed to play a critical role in how the body mobilizes glucose in response to stress. By examining these neurons, the study aims to uncover the mechanisms behind nutrient mobilization, which is essential for survival during stressful situations. The research employs advanced techniques such as single nucleus RNA sequencing to analyze the activity and connections of these neurons, providing insights into their function in regulating glucose and lipid levels. This could lead to a better understanding of how chronic stress affects metabolism and contributes to conditions like diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic stress or metabolic disorders such as diabetes.
Not a fit: Patients who do not experience stress-related metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing stress-related metabolic disorders, including diabetes.
How similar studies have performed: Previous research has shown success in understanding the role of brain circuits in metabolic regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Affinati, Alison Holley — University of Michigan at Ann Arbor
- Study coordinator: Affinati, Alison Holley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.