Understanding how specific brain neurons control fat tissue and energy balance
Official title: VMH SF1 neurons-originated sympathetic circuits modulating iWAT and iBAT
Funded at Albert Einstein College of Medicine · NIH-11058500 · Data updated 2026-11-12
This study is looking at special brain cells that help control how our body uses fat, which could lead to new ways to manage obesity and improve metabolic health for people struggling with weight issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | April 17, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $453,296 |
| NIH project number | 5R01DK135717-03 |
| Project ID | NIH-11058500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or metabolic disorders who are seeking innovative treatment options.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the role of specific neurons in the brain, known as VMH SF1 neurons, in regulating fat tissue functions that are crucial for managing obesity and related metabolic issues. By examining how these neurons influence energy expenditure and heat generation, the study aims to uncover the mechanisms behind fat tissue modulation. The researchers will use advanced techniques to stimulate these neurons and observe their effects on different types of fat tissue, which could lead to new strategies for treating obesity. Patients may benefit from insights gained into how to better manage body weight and metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and metabolic disorders by enhancing our understanding of energy balance and fat tissue regulation.
How similar studies have gone: Previous research has shown promising results in understanding brain control over fat tissue, suggesting that this approach could yield significant insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Yang, Yunlei — Albert Einstein College of Medicine
- Study coordinator: Yang, Yunlei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.