Understanding how specific brain neurons affect chronic pain
Delineating how Calca neurons in the parabrachial nucleus mediate chronic pain
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF WASHINGTON · NIH-10901885
This study is looking at how certain brain cells called Calca neurons affect chronic pain, and by understanding their role, we hope to find new ways to help people manage their pain better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10901885 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Calca neurons in the parabrachial nucleus of the brain in relation to chronic pain. By using a model of chronic pain induced by partial nerve ligation, the study aims to observe how these neurons behave and contribute to the experience of pain over time. The approach includes manipulating the activity of these neurons to determine their impact on pain perception, which could lead to new insights into pain management. Patients may benefit from findings that could inform future treatments for chronic pain conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions, such as fibromyalgia or other nociplastic pain syndromes.
Not a fit: Patients with acute pain conditions or those not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic pain.
How similar studies have performed: Previous research has shown promise in understanding the neural mechanisms of chronic pain, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONDON, LOGAN FRANCIS — UNIVERSITY OF WASHINGTON
- Study coordinator: CONDON, LOGAN FRANCIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.