Understanding how specific brain neurons affect alcohol cravings and consumption
The role of BNST PKCdelta neurons in compulsive ethanol intake
['FUNDING_CAREER'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11053130
This study is looking at how certain brain cells might affect drinking habits in people with Alcohol Use Disorder, using animal models to understand different drinking patterns and cravings when they're not drinking, with the hope of finding better treatments for those dealing with alcohol addiction.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11053130 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific neurons in the brain that may influence compulsive drinking behaviors in individuals with Alcohol Use Disorder (AUD). By using animal models, the study aims to identify different drinking patterns and cravings during periods of abstinence from alcohol. The researchers will employ a method called Structured Tracking of Alcohol Reinforcement (STAR) to observe how these neurons behave in response to alcohol-seeking behaviors. The goal is to uncover insights that could lead to targeted treatments for those struggling with alcohol addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing challenges with alcohol use and are seeking treatment.
Not a fit: Patients who are not struggling with alcohol use or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for individuals with Alcohol Use Disorder, helping to reduce cravings and improve abstinence outcomes.
How similar studies have performed: Previous research has shown promise in understanding the neurobiological mechanisms of addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOYLE, MARIE ALTHEA — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: DOYLE, MARIE ALTHEA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder