Understanding how specific brain circuits control escape behavior during panic attacks
Dissecting Cell-Specific Brainstem Circuits Mediating Escape Behavior
This study is looking at how certain brain cells help control panic attacks, focusing on a specific area of the brain, and it aims to find out how these cells react when faced with danger, which could lead to better treatments for people who experience panic disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10883550 on NIH RePORTER |
What this research studies
This research investigates the brain circuits involved in panic attacks, particularly focusing on a region called the periaqueductal gray (PAG). By studying genetically identified neurons that express a neuropeptide called cholecystokinin (cck), the research aims to understand how these neurons influence escape behaviors in response to threats. Using advanced techniques like chemogenetics and calcium imaging in mice, the researchers will explore how these brain cells activate during panic situations. This could lead to new insights into panic disorders and improve treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing panic disorder or related anxiety conditions.
Not a fit: Patients with panic disorder who do not respond to treatments or have other underlying neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for panic disorder, improving the quality of life for many patients.
How similar studies have performed: Previous research has shown promise in understanding panic mechanisms through similar approaches, but this specific investigation into cck+ neurons is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Torossian, Anita — University of California Los Angeles
- Study coordinator: Torossian, Anita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.