Understanding how specific brain circuits control appetite
Dissecting a central amygdala-parasubthalamic nucleus circuitry underlying appetite control
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11044058
This study is looking at how certain brain cells help control hunger and weight, especially how they respond to signals from your stomach, to find new ways to treat obesity and eating disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11044058 on ClinicalTrials.gov |
What this research studies
This research investigates the neural mechanisms that regulate appetite and body weight, focusing on a specific group of neurons in the central amygdala that respond to appetite-suppressing signals from the gut. By using advanced genetic techniques, the study aims to identify how these neurons interact with other brain regions to influence feeding behavior. The ultimate goal is to develop targeted therapies for obesity and eating disorders by understanding these complex neural circuits.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who struggle with obesity or eating disorders.
Not a fit: Patients who are under 21 years old or do not have issues related to appetite regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and eating disorders by targeting specific brain circuits involved in appetite control.
How similar studies have performed: While the specific neural circuits being studied are novel, previous research has shown promise in understanding appetite regulation through similar mechanisms.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAI, HAIJIANG — UNIVERSITY OF ARIZONA
- Study coordinator: CAI, HAIJIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.