Understanding how specific brain channels affect the fading of cocaine-related memories
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memories
['FUNDING_R01'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11094909
This study is looking at how certain brain channels help with learning and memory, especially in people recovering from cocaine addiction, to find better ways to prevent relapse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11094909 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Cav1.2 channels in the dorsal hippocampus, which is crucial for learning and memory, particularly in the context of cocaine addiction. The study aims to uncover how these channels contribute to the extinction of memories associated with cocaine use, which is vital for preventing relapse in individuals recovering from addiction. By exploring the neural mechanisms behind drug-context associations, the research seeks to develop better treatment options for cocaine dependence. Patients may benefit from insights that could lead to new therapeutic strategies aimed at reducing relapse rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with cocaine addiction who are at risk of relapse.
Not a fit: Patients who are not addicted to cocaine or those who have not previously used cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly reduce relapse rates in individuals recovering from cocaine addiction.
How similar studies have performed: Previous research has shown promise in understanding the neural mechanisms of addiction, but this specific approach focusing on Cav1.2 channels is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAJADHYAKSHA, ANJALI M — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: RAJADHYAKSHA, ANJALI M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder