Understanding how specific brain channels affect breathing in Rett syndrome
Official title: Contributions of Astrocyte Kir4.1/5.1 Channels to Disordered Breathing in Rett Syndrome
Funded at University of Connecticut Storrs · NIH-10987006 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes help control breathing in people with Rett syndrome, and it hopes to find out how problems with these cells might affect breathing, which could lead to better understanding and help for those with the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | January 6, 2023 |
| Project end | January 5, 2027 |
| Funding year | 2025 |
| Award (this year) | $45,994 |
| NIH project number | 5F31HL167553-03 |
| Project ID | NIH-10987006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Rett syndrome, particularly those experiencing disordered breathing.
✕Less likely to help
Patients without Rett syndrome or those not experiencing breathing difficulties may not benefit from this research.
What this research studies
This research investigates the role of astrocyte channels in regulating breathing patterns in individuals with Rett syndrome, a severe neurodevelopmental disorder. By studying mouse models, the research aims to understand how disruptions in these channels affect the body's ability to respond to changes in carbon dioxide and acidity levels, which are crucial for normal breathing. The approach involves examining the function of specific channels in astrocytes, which are supportive cells in the brain, to determine their impact on breathing regulation. The findings could lead to new insights into the mechanisms behind breathing difficulties in Rett syndrome patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for breathing disorders in Rett syndrome, enhancing the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocyte channels in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Strain, Monica — University of Connecticut Storrs
- Study coordinator: Strain, Monica
Related research
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Studying how deep brain stimulation helps Rett syndrome in mice
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Molecular Pathways Behind Rett Syndrome in Humans
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.