Understanding how specific brain cells influence drug cravings after quitting
Differential Roles of Prefrontal Cortical Interneurons in Drug Seeking after Withdrawal
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11126864
This study is looking at how certain brain cells in the prefrontal cortex affect cravings for drugs like cocaine after someone has stopped using them, with the hope of finding new ways to help people manage their cravings and avoid relapse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11126864 on ClinicalTrials.gov |
What this research studies
This research investigates the role of different types of brain cells, specifically interneurons in the prefrontal cortex, in driving drug-seeking behavior after a period of abstinence. By using advanced imaging techniques like 2-photon microscopy, the study aims to uncover the neural mechanisms that contribute to cravings for drugs such as cocaine. The goal is to better understand how these brain circuits change during addiction and withdrawal, which could lead to new treatment strategies for substance abuse. Patients may benefit from insights gained about how to manage cravings and reduce the risk of relapse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced substance abuse and are currently in a period of abstinence.
Not a fit: Patients who have not struggled with substance abuse or those currently using drugs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help individuals manage cravings and reduce the likelihood of relapse in drug addiction.
How similar studies have performed: Previous research has shown promising results in understanding brain mechanisms related to addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, BYUNGKOOK — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: LIM, BYUNGKOOK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder