Understanding how specific brain cells help clear debris in white matter degeneration.
Interrogating a white matter degeneration-specific astrocyte reactivity state and its role in governing repair-associated microglia specification and function.
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11030312
This study is looking at how special brain cells work together to help clean up damage in the brain, which could lead to new treatments for people with Multiple Sclerosis and injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11030312 on ClinicalTrials.gov |
What this research studies
This research investigates how certain brain cells, specifically astrocytes, interact with microglia to clear cellular debris in the central nervous system, particularly in conditions like Multiple Sclerosis and traumatic injuries. By using advanced techniques such as single-nucleus RNA sequencing and mouse models, the study aims to uncover the molecular pathways that enhance the brain's ability to repair itself after damage. Patients may benefit from insights that could lead to new therapies aimed at improving debris clearance and reducing inflammation in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from conditions that involve white matter degeneration, such as Multiple Sclerosis or those recovering from traumatic brain injuries.
Not a fit: Patients with conditions unrelated to white matter degeneration or those who do not have significant neuroinflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the brain's repair mechanisms and improve outcomes for patients with white matter degeneration.
How similar studies have performed: Previous research has shown promise in understanding the role of astrocytes and microglia in brain repair, indicating that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURDA, JOSHUA EVAN — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: BURDA, JOSHUA EVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Disease, acute disease/disorder, acute disorder