Understanding how specific brain cells control movement and are affected in Parkinson's disease
Investigation of Pallidal Neurons in Motor Inhibition
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10847969
This study is looking at how certain brain cells in a part of the brain that helps control movement work together, especially in people with Parkinson's disease, to better understand why movement can be difficult and to help find new ways to improve treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10847969 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neurons in the external globus pallidus, a part of the brain involved in movement control, particularly in the context of Parkinson's disease. By using advanced genetic tools and techniques, the researchers aim to identify different types of neurons in this area and how they interact to regulate motor activity. The study will involve examining these neurons in both healthy and Parkinson's disease models to uncover the mechanisms that lead to movement difficulties. This research could provide valuable insights into how motor function is disrupted in Parkinson's disease and potentially guide future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with Parkinson's disease or exhibit motor control issues.
Not a fit: Patients with movement disorders unrelated to the basal ganglia or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Parkinson's disease, particularly in managing motor symptoms.
How similar studies have performed: Previous research has shown promising results in understanding the basal ganglia's role in movement, suggesting that this approach could yield significant insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAN, SAVIO — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CHAN, SAVIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.