Understanding how specific brain cells connect and function
Molecular mechanisms underlying cortical interneuron synaptic specificity
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11001965
This study is looking at how special brain cells called chandelier cells connect with other neurons, which is important for keeping our brain working well, and it could help us understand conditions like autism and schizophrenia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11001965 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that govern how inhibitory GABAergic interneurons (INs) form specific connections within the brain. By focusing on chandelier cells, which play a crucial role in regulating the activity of pyramidal neurons, the study aims to uncover the unique ways these cells connect at different levels in the brain. The research employs advanced experimental techniques to analyze the wiring of these interneurons, which is essential for maintaining normal brain function and could shed light on disorders like autism and schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, schizophrenia, or other related brain disorders.
Not a fit: Patients with purely physical health issues unrelated to brain function or neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of brain disorders associated with dysfunctional neuronal connections.
How similar studies have performed: Previous research has shown promising results in understanding the role of specific brain cell types in various neurological conditions, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TANIGUCHI, HIROKI — OHIO STATE UNIVERSITY
- Study coordinator: TANIGUCHI, HIROKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder