Understanding how specific brain cells change with age
Defining Roles for Astrocyte Subpopulations in the Aging Brain
This study is looking at how a special type of brain cell, called CD51+ astrocytes, affects brain function as we get older, and it aims to understand how a protein called Sox9 helps control these cells, which could help us learn more about why our thinking might change with age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11052504 on NIH RePORTER |
What this research studies
This research investigates the roles of different types of astrocytes, a type of brain cell, in the aging brain, particularly focusing on a specific group marked by the CD51 protein. By using specially designed mouse models, the researchers aim to explore how these CD51+ astrocytes influence brain circuits and their functions as we age. The study will also examine the role of a transcription factor called Sox9 in regulating these astrocytes and their impact on brain health. This research could provide insights into the cellular mechanisms underlying age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing cognitive changes or are at risk for Alzheimer's disease.
Not a fit: Patients who are younger or do not have any cognitive impairments related to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related cognitive decline and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the roles of astrocytes in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Deneen, Benjamin — Baylor College of Medicine
- Study coordinator: Deneen, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.