Understanding how specific brain cells are involved in cocaine addiction
Official title: Characterization of cortical neuronal subtypes in cocaine self-administration
Funded at University of Washington · NIH-10815221 · Data updated 2026-11-12
This study is looking at how certain brain cells help with decision-making and rewards, especially in people dealing with cocaine addiction, to find better ways to treat and prevent relapse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $430,716 |
| NIH project number | 7R01DA047107-05 |
| Project ID | NIH-10815221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with a history of cocaine use or those at risk of developing addiction.
✕Less likely to help
Patients who are not affected by drug addiction or have no history of substance use may not receive benefit from this research.
What this research studies
This research investigates the role of different types of cortical neurons in the brain's decision-making and reward systems, particularly in relation to cocaine addiction. By examining how these neurons interact within the cortico-basal ganglia-thalamic network, the study aims to uncover the neurobiological changes that lead to addiction and relapse. The approach involves detailed biological assays to characterize neuronal subtypes and their functions, which could inform the development of more effective treatments for addiction. Patients may benefit from insights gained into the mechanisms of addiction, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals struggling with cocaine addiction.
How similar studies have gone: Previous research has shown promise in understanding the neurobiological mechanisms of addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Ferguson, Susan Marie — University of Washington
- Study coordinator: Ferguson, Susan Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.