Understanding how specific brain cells affect function and behavior
Multimodal analysis of primate infragranular pyramidal neurons and their modulation
This study is looking at how certain brain cells work and respond to signals, which could help us understand brain disorders like Alzheimer's and ALS better, so we can find more effective treatments for people affected by these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10893045 on NIH RePORTER |
What this research studies
This research investigates the role of specific types of neurons in the primate brain, particularly focusing on how their unique genetic expressions influence their function and response to various signals. By using advanced techniques like Patch-seq, researchers will analyze the properties of these neurons in both human and nonhuman primates. The goal is to uncover how differences in gene expression among neuron types contribute to brain disorders, which could lead to more targeted treatments for conditions like Alzheimer's disease and ALS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as Alzheimer's or ALS.
Not a fit: Patients with non-neurological conditions or those not diagnosed with neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for neurodegenerative diseases by targeting specific neuron types.
How similar studies have performed: Other research has shown promise in understanding neuron-specific contributions to brain disorders, indicating that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Allen Institute — Seattle, United States (Active)
Researchers
- Principal investigator: Kalmbach, Brian E. — Allen Institute
- Study coordinator: Kalmbach, Brian E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.