Understanding how specific brain cells affect blood flow in Alzheimer's disease
The Role of Pericytes in Brain Hypoperfusion in Alzheimer's Disease Development
This study is looking at how certain brain cells called pericytes help control blood flow and protect the brain in people with Alzheimer's disease, and it hopes to find new ways to support brain health for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11014431 on NIH RePORTER |
What this research studies
This research investigates the role of pericytes, specialized cells in the brain, in regulating blood flow and maintaining the integrity of the blood-brain barrier in Alzheimer's disease. The study aims to understand how dysfunction in these cells contributes to decreased cerebral blood flow, which is an early symptom of Alzheimer's. Researchers will analyze brain tissue from Alzheimer's patients to assess levels of a specific transcription factor, Fli-1, and its impact on pericyte health and function. By exploring the mechanisms behind pericyte apoptosis and the effects of amyloid-beta, this research seeks to uncover potential therapeutic targets for improving brain health in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those exhibiting early symptoms of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease by targeting pericyte dysfunction.
How similar studies have performed: While the role of pericytes in Alzheimer's is an emerging field, preliminary studies have shown promising results in understanding their function, indicating potential for significant breakthroughs.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Fan, Hongkuan — Medical University of South Carolina
- Study coordinator: Fan, Hongkuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.