Understanding how specific antibodies can help treat food allergies
Official title: Convergent allergen-specific antibodies in food allergy
Funded at Massachusetts General Hospital · NIH-11030857 · Data updated 2026-11-12
This study is looking at how certain antibodies can help people with peanut allergies by finding new ways to make them feel better and reduce allergic reactions, and it invites patients to join in to help discover these helpful antibody responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 7, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $809,948 |
| NIH project number | 5R01AI182001-02 |
| Project ID | NIH-11030857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with peanut allergies, particularly those who have experienced severe allergic reactions.
✕Less likely to help
Patients with food allergies other than peanuts or those who do not have a history of severe allergic reactions may not benefit from this research.
What this research studies
This research investigates the role of specific antibodies in food allergies, particularly focusing on peanut allergies, which affect a significant portion of the population. The study aims to understand how immunotherapy can induce beneficial antibodies that disrupt harmful interactions between allergens and IgE antibodies, which are responsible for allergic reactions. By examining the molecular interactions of these antibodies, the research seeks to uncover new therapeutic strategies for managing food allergies and improving patient outcomes. Patients may be involved in the research to help identify effective antibody responses and their mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new antibody-based treatments that significantly reduce the severity of allergic reactions in patients with food allergies.
How similar studies have gone: Previous research has shown promise in using antibody therapies for food allergies, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Patil, Sarita U — Massachusetts General Hospital
- Study coordinator: Patil, Sarita U
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.